occupational diseases remain a significant public health concern globally, imposing substantial burdens on individuals, healthcare systems, and economies. This study synthesizes evidence-based practices and successful case studies in occupational disease prevention, with a focus on pneumoconiosis, occupational noise-induced hearing loss, and occupational poisoning. A comprehensive literature review and analysis of documented workplace interventions were conducted to identify effective preventive strategies and early detection methods. Findings indicate that engineering controls, including ventilation systems, noise barriers, and enclosed processes, are the most effective primary prevention measures. Administrative controls, such as rotating shift schedules and exposure time reduction, complement these efforts. Personal protective equipment serves as the last line of defense but requires proper selection, fitting, and consistent use. Early identification through periodic health surveillance, biological monitoring, and biomarker assessment enables timely intervention and prevents disease progression. Successful case studies from manufacturing, mining, and chemical industries demonstrate that integrated prevention programs combining multiple control strategies, worker education, and management commitment can reduce occupational disease incidence by 60-80%. The study concludes that a multi-layered prevention approach, coupled with robust health surveillance systems and a strong safety culture, is essential for effective occupational disease prevention. These findings provide practical guidance for enterprises to develop comprehensive occupational health programs.